The Biomedical Research Centre

Journal Articles

Baggiolini, M., Moser, B., and Clark-Lewis, I. Interleukin-8 and related chemotactic cytokines. CHEST,105 uppl.:95S-98S (1994).

Bures, E.J., Nika, H., Hess, D., Morrison, H.D., and Aebersold, R. Synthesis of the protein sequencing reagent 4-(3-pyridinylmethyl-aminocarboxypropyl) phenyl isothiocyanate and characterization of 4-(3-pyridinylmethyl-aminocarboxypropyl) phenylthiohydantoins. J. Anal. Biochem.,224:364-372 (1994).

Chakrabarti, A.C., Clark-Lewis, I., and Cullis, P.R. Influence of charge, charge distribution and hydrophobicity on the transport of short model peptides into liposomes in response to transmembrane pH gradients. Biochemistry, 33:8479-8485 (1994).

Chui, D., Ong, C.J., Johnson, P., Teh, H.-S., and Marth, J.D. Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J., 13:798-807 (1994).

Clark-Lewis, I., Dewald, B., Loetscher, M., Moser, B., and Baggiolini, M. Structural requirements for IL-8 function identified by design of analogs and CXC chemokine hybrids. J. Biol. Chem., 269:16075-16081 (1994).

Dawson, P.E., Muir, T.W., Clark-Lewis, I., and Kent, S.B.H. Synthesis of proteins by native chemical ligation. Science, 266:776-779 (1994).

Daya-Makin, M., Sanghera, J.S., Morgentale, T.L., Lipp, M., Parchomchuk, J., Hogg, J.C., and Pelech, S.L. Activation of a tumor- ssociated protein kinase (p40 TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung. Cancer Res., 54:2262-2268 (1994).

Dechert, U., Adam, M., Harder, K.W., Clark-Lewis, I., and Jirik, F.R. Characterization of the protein tyrosine phosphatase SH-PTP2: Study of phosphopeptide substrates and possible regulatory roles of SH2-domains. J. Biol. Chem., 269:5602-5611 (1994).

Ellies, L.G., Tomlinson-Jones, A., Williams, M.J., and Ziltener, H.J. Differential regulation of CD43 glycoforms on CD4+ and CD8+ T lymphocytes in graft-versus-host disease. Glycobiology, 4:885-893 (1994).

Goebel, T.W., Chen, C.-L., Lahti, J., Kubota, T., Kou, C.-L., Aebersold, R., Hood, L., and Cooper, M.D. Identification of T-cell receptor alpha-chain genes in the chicken. Proc. Natl. Acad. Sci. USA, 91:1094-1098 (1994).

Gold, M.R. and Aebersold, R. Both phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B Cells. J. Immunol., 152:42-50 (1994).

Gold, M.R., Chiu, R., Ingham, R.J., Saxton, T.M., van Oostveen, I., Watts, J.D., Affolter, M., and Aebersold, R. Activation and serine phosphorylation of the p56 lck protein-tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes. J. Immunol., 153:2369-2380 (1994).

Gold, M.R., Duronio, V., Saxena, S.P., Schrader, J.W. and Aebersold, R. Multiple cytokines activate phosphatidylinositol 3-kinase in hematopoietic cell lines. Association of the enzyme with various tyrosine phosphorylated substrates. J. Biol. Chem., 269:5403-5412 (1994).

Gu, H., Marth, J.D., Orban, P.C., Mossmann, H., and Rajewsky, K. Deletion of the DNA polymerase beta gene in T cells using tissue-specific gene targeting. Science, 265:103-106 (1994).

Harder K.W., Wong, L., Owen, P., Aebersold, R., Clark-Lewis, I., and Jirik, F.R. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase b (HPTP-b) using synthetic phosphopeptides. Biochem. J., 298:395-401 (1994).

Hei Y.-J., Pelech S.L., Chen X., Diamond J., and McNeill J.H. Purification and characterization of a novel ribosomal S6 kinase from skeletal muscle of insulin-treated rats. J. Biol. Chem., 269:7816-7823 (1994).

Herbelin, A., Machavoine, F., Vicari, A., Schneider, E., Papiernik, M., Ziltener, H.J., Penit, C., and Dy, M. Endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in IL-1- and IL-7-induced murine thymocyte proliferation. J. Immunol., 153:1973-1981 (1994).

Hess, D., Nika, H., Bures, E.J., Chow, D., Morrison, H.D., and Aebersold, R. Liquid chromatography-electrospray ionization mass spectrometry of 4-(3-pyridinylmethyl-amino-carboxypropyl) phenylthiohydantoins. J. Anal. Biochem., 224:373-381 (1994).

Kim, K.-S., Clark-Lewis, I., and Sykes, B.D. Solution structure of GRO/MGSA determined by 1H NMR spectroscopy. J. Biol. Chem., 269:32909-32915 (1994).

L'Etoile, N.D., Fahnestock, M.L., Shen, Y., Aebersold, R. and Berk, A.J. Human TFIIIC Box B-binding subunit. Proc. Natl. Acad. Sci. USA, 91:1652-1656 (1994).

Lee, G.I., Nakai, S., and Clark-Lewis, I. Enzymatic synthesis of two sweet aspartyl dipeptide analogs catalyzed by thermolysin. Food Res. Int., 27:483-488 (1994).

Liu, M.-S., Jirik, F.R., LeBoeuf, R.C., Henderson, H., Castellani, L.W., Lusis, A.J., Ma, Y., Forsythe, I.J., Zhang, H., Kirk, E., Brunzell, J.D., and Hayden, M.R. Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase. J. Biol. Chem., 269:11417-11424 (1994).

Loetscher, P., Seitz, M., Clark-Lewis, I., Baggiolini, M., and Moser, B. Both interleukin-8 receptors independently mediate chemotaxis: Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GROa and NAP-2. FEBS Lett., 341:187-192 (1994).

Loetscher, P., Seitz, M., Clark-Lewis, I., Baggiolini, M., and Moser, B. The monocyte chemotactic proteins, MCP-1, MCP-2 and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes. FASEB J., 8:1055-1060 (1994).

Lotz, M., Clark-Lewis, I., and Ganu, V. HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes. J. Cell. Biol., 124:365-371 (1994).

Ma, Y., Henderson, H.E., Liu, M.-S., Zhang, H., Forsythe, I.J., Clark-Lewis, I., Hayden, M.R., and Brunzell, J.D. Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase. J. Lipid Res., 35:2049-2059 (1994).

Marth, J.D. Will the transgenic mouse serve as a Rosetta Stone to glycoconjugate function? Glycoconjugate J., 11:3-8 (1994).

Marth, J.D., Ong, C.J., and Chui, D. Specific CD45 isoforms regulate T cell ontogeny and are functionally distinct in modifying immune activation. Adv. Exp. Med. Biol., 365:149-166 (1994).

Mastick, C.C., Aebersold, R. and Lienhard, G.E. Characterization of a major protein in GLUT4 vescicles: Concentration in the vescicles and insulin-stimulated translocation to the plasma membrane. J. Biol. Chem., 269:6089-6092 (1994).

Metzler, M., Gertz, A., Sarkar, M., Schachter, H., Schrader, J.W., and Marth, J.D. Complex asparagine-linked oligosaccharides are required for morphogenetic events during post-implantation development. EMBO J., 13:2056-2065 (1994).

Miao, S., McCarter, J.D., Grace, M.E., Grabowski, G.A., Aebersold, R. and Withers, S.G. Identification of Glu 340 as the active site nucleophile in human glucocerebrosidase by use of electrospray tandem mass spectrometry. J. Biol. Chem., 269:10975-10978 (1994).

Miao, S., Ziser, L., Aebersold, R., and Withers, S.G. Identification of glutamic acid 78 as the active site nucleophile in Bacillus subtilis xylanase using electrospray tandem mass spectrometry. Biochemistry, 33:7027-7032 (1994).

Milich, D.R., Jones, J.E., Hughes, J.L., Toshiyuki, M., Melhado, I., and Jirik, F.R T-cell tolerance to the intranuclear hepatitis B core antigen expressed extrathymically in transgenic mice. J. Immunol., 152:455-466 (1994).

Ong, C.J., Chui, D., Teh, H.-S., and Marth, J.D. Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection. J. Immunol., 152:3793-3805 (1994).

Pelech, S.L. Mitogen-activated protein kinases: At the cross-roads of diverse signal transduction pathways. Bulletin of the Canadian Society of Biochemistry and Molecular Biology, Spring:15-19 (1994).

Pelech, S.L. Mitogen-activated protein kinase modules in signal transduction. Upstate Biotechnology Inc. Biosignals, Summer: 2-16 (1994).

Pignata, C., Sanghera, J.S., Cossette, L., Pelech, S.L., and Ritz, J. Interleukin-12 induces tyrosine phosphorylation and activation of 44 kD mitogen-activated protein kinase in human T cells. Blood, 83:184-190 (1994).

Quamme, G., Pelech, S., Biber, J. and Murer, H. Abnormalities of parathyroid hormone-mediated signal transduction mechanisms in opossum kidney cells. Biochim. Biophys. Acta., 1223:107-116 (1994).

Rajarathnam, K., Clark-Lewis, I., and Sykes, B.D. 1H NMR studies of interleukin-8 analogs: Characterization of the domains essential for function. Biochemistry, 33:6623-6630 (1994).

Rajarathnam, K., Sykes, B.D., Kay, C.M., Geiser, T., Dewald, B., Baggiolini, M., and Clark-Lewis, I. Neutrophil activation by monomeric interleukin-8. Science, 264:90-92 (1994).

Roberge, M., Tudan, C., Hung, S.M.F., Harder, K.W., Jirik, F.R., and Anderson, H. The antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A. Cancer Res., 54:6115-6121 (1994).

Salachas, F., Schneider, E., Lemoine, F.M., Lebel, B., Daëron, M., Navarro, S., Ziltener, H.J., and Dy, M. Aggregated IgE mimic IL-3-induced histamine synthesis by murine hematopoietic progenitors. Blood, 84:1098-1107 (1994).

Tang, L., Pelech, S.L., and Berger, J.A. cdc2-like kinase associated with commitment to division in Paramecium tetraurelia. J. Euk. Microbiol., 41:381-387 (1994).

Tomlinson-Jones, A., Federsppiel, B., Ellies, L.G., Williams, M.J., Burgener, R., Duronio, V., Smith, C.A., Takei, F., and Ziltener, H.J. Characterization of the activation associated isoform of CD43 on murine T lymphocytes. J. Immunol., 153:3426-3439 (1994).

Wang, J., Wallace, C.J.A., Clark-Lewis, I., and Caffrey, M. Structural characterization of membrane bound and surface adsorbed proteins. J. Mol. Biol., 237:1-4 (1994).

Wang, Q., Dechert, U., Jirik, F., and Withers, S. Suicide inactivation of human prostatic acid phosphatase and a protein tyrosine phosphatase. Biochem. Biophys. Res. Comm., 200:577-583 (1994).

Watari, K., Lansdorp, P.M., Dragowska, W., and Schrader, J.W. Detection of interleukin-1b mRNA in candidate human hematopoietic stem cells. Blood, 84:36-43 (1994).

Watts, J.D., Affolter, M., Krebs, D.L., Wange, R.L., Samelson, L.E., and Aebersold, R. Identification by electrospray ionization mass spectrometry the sites of tyrosine phosphorylation induced in Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem., 269:29520-29529 (1994).

Weber, M., Uguccioni, M., Ochensberger, B., Baggiolini, M., Clark-Lewis, I., and Dahinden, C.A. The monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes and has functional similarity to MCP-3. J. Immunol., 154:4166-4172 (1994).

Welham, M.J., Dechert, U., Leslie, K.B., Jirik, F., and Schrader, J.W. IL-3 and GM-CSF, but not IL-4, induce tyrosine phosphorylation, activation and association of SH-PTP2 with grb2 and PI3' kinase. J. Biol. Chem., 269:23764-23768 (1994).

Welham, M.J., Duronio, V., and Schrader, J.W. Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth. J. Biol. Chem., 269:5865-5873 (1994).

Welham, M.J., Duronio, V., Leslie, K.B., Bowtell, D., and Schrader, J.W. Involvement of Shc and mSos-1 in cytokine-mediated control of p21ras activity. J. Biol. Chem., 269:21165-21176 (1994).

Winz, R., Hess, D., Aebersold, R. and Brownsey, R.W. Unique structural features and differential phosphorylation of the 280kDa component (Isozyme) of rat liver acetyl-CoA-carboxylase. J. Biol. Chem., 269:1-8 (1994).

Zhang, W., Yungwirth, T., Czernik, A.J., Chait, B.T., and Aebersold, R. Matrix-assisted laser desorption mass spectrometric peptide mapping of proteins separated by 2D Gel electrophoresis: Determination of
phosphorylation in synapsin 1. Protein Science, 3:677-686 (1994).

Zhong, Q., Clark-Lewis, I., and Cushley, R.J. Secondary structure of lipid associating peptides: A fourier-transform infrared study. Peptide Res., 7:99-106 (1994).

Ziltener, H.J., Clark-Lewis, I., Tomlinson-Jones, A., and Dy, M. Carbohydrate does not modulate the in vivo effects of injected interleukin-3. Exp. Hematol., 22:1070-1075 (1994).

Books and Book Chapters

Schrader, J.W. Interleukin-3. In: Guidebook to Cytokines and Their Receptors (ed. Nicola, N.) Sambrook and Tooze, Oxford University Press, pp.81-98 (1994).

Schrader, J.W. Interleukin-3. In: The Cytokine Handbook, 2nd Edition, (ed. Thompson, A.), Academic Press Ltd., London (1994).

Schrader, J.W. Colony Stimulating Factors and the Skin. Epidermal Cytokines and Growth Factors, eds. Luger, T.A. & Schwarz, T., Marcel Dekker, NY, pp. 147-162 (1994).