The Biomedical Research Centre

Journal Articles

Barran, P., Fellinger, W., Warren, C., Dennis, J.W. and Ziltener, H.J. Modification of CD43 and other lymphocyte O-glycoproteins by core 2 N-acetylglucosaminyltransferase. Glycobiology, 7: 129-136 (1997).

Bone, H. Dechert, U., Jirik, F., Schrader, J.W. and Welham, M.J. SHP1 and SHP2 protein tyrosine phosphatases associate with Bc after Interleukin-3-induced receptor tyrosine phosphorylation: Identification of potential binding sites and substrates. J. Biol. Chem., 272(22): 14470-14476 (1997).

Coulin, F., Power, C.A., Alouani, S., Peitsch, M.C., Schroeder, J.-M., Moshizuki, M., Clark-Lewis, I. and Wells, T.N.C. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage inflammatory protein family of chemokines. Eur. J. Biochem., 248: 507-515 (1997).

Crump, M.P., Gong, J.-H., Loetscher, P., Rajarathnam, K., Amara, A., Arenzana-Seisdedos, F., Virelizier, J.-L., Baggiolini, M., Sykes, B.D. and Clark-Lewis, I. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J. ,16: 6996-7007 (1997).

Apuzzo, M., Rolink, A., Loetscher, M., Hoxie, J.A., Clark-Lewis, I., Melchers, F., Baggiolini, M. and Moser, B. The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur J. Immunol., 27: 1788-1793 (1997).

Foltz, I.N., and Schrader, J.W. Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of Interleukin-4. Blood, 89: 3092-3096 (1997).

Geras‹Raaka, E., Varma, A., Clark-Lewis, I. and Gershengorn, M.C. Human IP10 inhibits constitutive signaling if Kaposios sarcoma associated Hepes virus G protein coupled receptor J. Exp. Med., 188: 405-408 (1998).

Gong, J.-H., Ratkay, L., Waterfield, D. and Clark-Lewis, I. An antagonist of monocyte chemoattractant protein-1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J. Exp. Med. ,186: 131-137 (1997).

Hoogewerf, A.J., Kruschert, G.S.V., Proudfoot, A.E.I., Borlat, F., Clark-Lewis, I., Power, C.A. and Wells, T.N.C. Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry, 36: 13570-13578 (1997).

Iverson, P.O., Robinson, D., Ying, S., Meng, Q., Kay, A.B., Clark-Lewis, I. and Lopez, A.F. The GM-CSF analogue E21R induces apoptosis of normal, asthmatic and activated eosinophils. Am. J. Resp. Crit. Care Med., 156: 1628-1632 (1997).

Jones, S.A. , Dewald, B., Clark-Lewis, I. and Baggiolini, M. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. J. Biol. Chem., 272: 16166-16169 (1997).

Lalani, A.S., Graham, K., Mossman, K., Rajarathnam, K., Clark-Lewis, I., Kelvin, D. and McFadden, G. The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines. J. Virol.,71: 4356-4363 (1997).

Kledal, T.N., Rosenkilde, M.M., Coulin, F., Simmons, G., Johnsen, A.H., Alouani, S., Power, C.A., Lüttichau, J., Gerstoft, J., Clapham, P.R., Clark-Lewis, I., Wells, T.N.C. and Schwartz, T.W. A broad-spectrum chemokine antagonist encoded by Kaposi¹s sarcoma-associated herpes virus Science, 277: 1656-1659 (1997).

McLean, G.R., Pathare, P.M., Wilbur, D.S., Morgan, A.C., Woodhouse, C.S., Schrader, J.W. and Ziltener, H.J. Cobalamin analogs modulate the growth of leukemia cells in vitro. Cancer Research, 57 (18): 4015-4022 (1997).

McLean, G.R., Quadros, E.V., Rothenberg, S.P., Morgan, C., Schrader, J.W. and Ziltener, H.J. Antibodies to transcobalamin II block in vitro proliferation of leukemic cells. Blood, 89: 235-242 (1997).

Middleton, J., Neil, S., Wintle, J., Clark-Lewis, I., Moore, H., Lam, C., Auer, M., Hub, E. and Rot, A. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell, 91: 385-395 (1997).

Orchansky, P.L., Ayres, S.D., Hilton, D.J., and Schrader, J.W. An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4. J. Biol Chem., 272(36): 22940-22947 (1997).

Palaty, C.K., Clark-Lewis, I., Leung, D. and Pelech, S.L. Phosphorylation site substrate specificity determinants for the Pim-1 protooncogene- encoded protein kinase. Biochem. Cell. Biol., 75: 153-162 (1997).

Piali, L., Weber, C., La Rosa, G., Mackay, C.R., Springer, T.A., Clark-Lewis, I. and Moser, B. The chemokine receptor CXCR3 mediates rapid and shear resistant adhesion induction by the chemokines IP10 and Mig. Eur. J. Immunol., 28: 961-972 (1997).

Power, C.A., Church, D.J., Meyer, A., Alouani, S., Proudfoot, A.E.I., Clark-Lewis, I., Sozzani, S., Mantovani, A. and Wells, T.N.C. Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3-alpha from lung dendritic cells. J. Exp. Med.,186: 825-835 (1997).

Roos, R.S., Loetscher, M., Leger, D.F., Clark-Lewis, I., Baggiolini, M. and Moser, B. Identification of CCR8, the receptor for the human CC chemokine I-309. J. Biol. Chem., 272: 17251-17254 (1997).

Salmon, R.A., Foltz, I.N., Young, P.R., and Schrader, J.W. The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors. J. Immunol., 159(11): 5309-5317 (1997).

Tessier, P.A., Naccache, P.H., Clark-Lewis, I., Gladue, R.P., Neote, K.S. and McColl, S.R. Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. J. Immunol.,159: 3595-3602 (1997).

Wallace, C.J.A. and Clark-Lewis, I. A rationale for the absolute conservation of Asn70 and Pro71 in mitochondrial cytochrome c suggested by protein engineering. Biochemistry,36: 14733-14740.

Books and Book Chapters

Clark-Lewis, I., Anderson, J., Owen, P.L., Vo, L., and Gong, J.-H. Structure activity relationships of growth factors and chemokines, In: Growth factors and receptors: a practical approach, eds. Mckay, I.A. and Brown, K.D., Oxford University Press, pp. 109-124 (1998).

Clark-Lewis, I., Vo, L., Owen, P.L. and Anderson, J. Chemical synthesis purification and folding of CXC and CC chemokines, Methods Enzmol., 287: 233-250 (1997).

Rajarathnam, K., Kay, C.M., Clark-Lewis, I. and Sykes, B.D. Characterization of quaternary structure of interleukin-8 and functional implications, Methods Enzymol., 287: 89-105 (1997).